Lanier Lab Publications

Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J.

J Exp Med. 2009 Oct 26;206(11):2469-81. Epub 2009 Oct 6. PMID: 19808259

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ 3rd, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF.

Blood. 2009 Nov 26;114(23):4823-31. Epub 2009 Oct 5. PMID: 19805616

Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection.

Sun JC, Ma A, Lanier LL.

J Immunol. 2009 Sep 1;183(5):2911-4. Epub 2009 Jul 31. PMID: 19648279

Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?

Sun JC, Lanier LL.

Eur J Immunol. 2009 Aug;39(8):2059-64. PMID: 19637199

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.

Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ.

J Exp Med. 2009 Jul 6;206(7):1603-14. Epub 2009 Jun 29. PMID: 19564354

Do the terms innate and adaptive immunity create conceptual barriers?

Lanier LL, Sun JC.

Nat Rev Immunol. 2009 May;9(5):302-3. PMID: 19396937

Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.

Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL.

J Exp Med. 2009 Apr 13;206(4):807-17. Epub 2009 Mar 30. PMID: 19332875

Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.

Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM.

J Exp Med. 2009 Mar 16;206(3):515-23. Epub 2009 Mar 2. PMID: 19255146

Adaptive immune features of natural killer cells.

Sun JC, Beilke JN, Lanier LL.

Nature. 2009 Jan 29;457(7229):557-61. Epub 2009 Jan 11. Erratum in: Nature. 2009 Feb 26;457(7233):1168. PMID: 19136945

DAP10- and DAP12-associated receptors in innate immunity.

Lanier LL.

Immunol Rev. 2009 Jan;227(1):150-60. PMID: 19120482

Cutting edge: viral infection breaks NK cell tolerance to "missing self".

Sun JC, Lanier LL.

J Immunol. 2008 Dec 1;181(11):7453-7. PMID: 19017932

Experimental malaria infection triggers early expansion of natural killer cells.

Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL.

Infect Immun. 2008 Dec;76(12):5873-82. Epub 2008 Sep 29. PMID: 18824529

Tolerance of NK cells encountering their viral ligand during development.

Sun JC, Lanier LL.

J Exp Med. 2008 Aug 4;205(8):1819-28. Epub 2008 Jul 7. PMID: 18606858

Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation.

Carr WH, Rosen DB, Arase H, Nixon DF, Michaelsson J, Lanier LL.

J Immunol. 2007 Jan 15;178(2):647-51. PMID: 17202323

DAP12: an adapter protein with dual functionality.

Takaki R, Watson SR, Lanier LL.

Immunol Rev. 2006 Dec;214:118-29. PMID: 17100880

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.

Mócsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA.

Nat Immunol. 2006 Dec;7(12):1326-33. Epub 2006 Nov 5. PMID: 17086186

Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL.

J Immunol. 2006 Aug 15;177(4):2051-5. PMID: 16887962

Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production.

Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ.

J Exp Med. 2006 Jun 12;203(6):1399-405. Epub 2006 May 30. PMID: 16735691

Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.

Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7012-7. Epub 2006 Apr 20. PMID: 16627620

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M.

Nature. 2006 Mar 23;440(7083):540-4. Epub 2006 Mar 8. PMID: 16525420

Inhibition of immune responses by ITAM-bearing receptors.

Hamerman JA, Lanier LL.

Sci STKE. 2006 Jan 31;2006(320):re1. PMID: 16449667

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.

Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC.

J Bone Miner Res. 2006 Feb;21(2):237-45. Epub 2005 Oct 20. PMID: 16418779

Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.

Rosen DB, Bettadapura J, Alsharifi M, Mathew PA, Warren HS, Lanier LL.

J Immunol. 2005 Dec 15;175(12):7796-9. PMID: 16339513

Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.

Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL.

J Exp Med. 2005 Dec 5;202(11):1477-82. Epub 2005 Nov 28. PMID: 16314433

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.

Humphrey MB, Lanier LL, Nakamura MC.

Immunol Rev. 2005 Dec;208:50-65. PMID: 16313340

Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.

Ogasawara K, Benjamin J, Takaki R, Phillips JH, Lanier LL.

Nat Immunol. 2005 Sep;6(9):938-45. Epub 2005 Aug 7. PMID: 16086018

IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.

Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth MJ, Lanier LL.

J Immunol. 2005 Aug 15;175(4):2167-73. PMID: 16081783

Missing self, NK cells, and The White Album.

Lanier LL.

J Immunol. 2005 Jun 1;174(11):6565. No abstract available. PMID: 15905491

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

Hamerman JA, Tchao NK, Lowell CA, Lanier LL.

Nat Immunol. 2005 Jun;6(6):579-86. Epub 2005 May 15. Erratum in: Nat Immunol. 2009 Feb;10(2):223. Dosage error in article text. PMID: 15895090

Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.

Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM.

Nat Genet. 2005 Jun;37(6):593-9. Epub 2005 May 15.

NK cell recognition.

Lanier LL.

Annu Rev Immunol. 2005;23:225-74. PMID: 15771571

Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.

Ehrlich LI, Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, Lanier LL.

J Immunol. 2005 Feb 15;174(4):1922-31. PMID: 15699119

The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions.

Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL.

J Exp Med. 2004 Oct 18;200(8):1075-81. Epub 2004 Oct 11. PMID: 15477345

CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.

Voehringer D, Rosen DB, Lanier LL, Locksley RM.

J Biol Chem. 2004 Dec 24;279(52):54117-23. Epub 2004 Oct 7. PMID: 15471863

Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.

Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL.

J Immunol. 2004 Sep 15;173(6):3716-24.PMID: 15356117

A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.

Rosen DB, Araki M, Hamerman JA, Chen T, Yamamura T, Lanier LL.

J Immunol. 2004 Aug 15;173(4):2470-8. PMID: 15294961

NKG2D blockade prevents autoimmune diabetes in NOD mice.

Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL.

Immunity. 2004 Jun;20(6):757-67. PMID: 15189740

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6158-63. Epub 2004 Apr 8. PMID: 15073337

Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).

Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A.

Int Immunol. 2004 Apr;16(4):533-8. PMID: 15039383

Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.

Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H.

J Exp Med. 2004 Feb 16;199(4):525-33. PMID: 14970179

Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor.

Hamerman JA, Ogasawara K, Lanier LL.

J Immunol. 2004 Feb 15;172(4):2001-5. PMID: 14764662

Natural killer cells and cancer.

Wu J, Lanier LL.

Adv Cancer Res. 2003;90:127-56. PMID: 14710949

NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.

Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL.

J Exp Med. 2003 May 19;197(10):1245-53. PMID: 12756263

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F.

Nat Immunol. 2003 Jun;4(6):565-72. Epub 2003 May 11. PMID: 12740576

Impairment of NK cell function by NKG2D modulation in NOD mice.

Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL.

Immunity. 2003 Jan;18(1):41-51. PMID: 12530974

Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells.

Ogasawara K, Yoshinaga SK, Lanier LL.

J Immunol. 2002 Oct 1;169(7):3676-85. PMID: 12244160

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.

Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL.

Science. 2002 May 17;296(5571):1323-6. Epub 2002 Apr 11. PMID: 11950999

Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D.

Cerwenka A, O'Callaghan CA, Hamerman JA, Yadav R, Ajayi W, Roopenian DC, Joyce S, Lanier LL.

J Immunol. 2002 Apr 1;168(7):3131-4. PMID: 11907062

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo.

Cerwenka A, Baron JL, Lanier LL.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11521-6. Epub 2001 Sep 18. PMID: 1156247

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.

O'Callaghan CA, Cerwenka A, Willcox BE, Lanier LL, Bjorkman PJ.

Immunity. 2001 Aug;15(2):201-11. PMID: 11520456

Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).

Arase H, Saito T, Phillips JH, Lanier LL.

J Immunol. 2001 Aug 1;167(3):1141-4. PMID: 11466327

Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes.

Shibuya A, Sakamoto N, Shimizu Y, Shibuya K, Osawa M, Hiroyama T, Eyre HJ, Sutherland GR, Endo Y, Fujita T, Miyabayashi T, Sakano S, Tsuji T, Nakayama E, Phillips JH, Lanier LL, Nakauchi H.

Nat Immunol. 2000 Nov;1(5):441-6. PMID: 11062505

Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.

Daws MR, Lanier LL, Seaman WE, Ryan JC.

Eur J Immunol. 2001 Mar;31(3):783-91. PMID: 11241283

Immune inhibitory receptors.

Ravetch JV, Lanier LL.

Science. 2000 Oct 6;290(5489):84-9. PMID: 11021804

DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.

Bakker AB, Hoek RM, Cerwenka A, Blom B, Lucian L, McNeil T, Murray R, Phillips LH, Sedgwick JD, Lanier LL.

Immunity. 2000 Sep;13(3):345-53. PMID: 11021532

DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.

Wu J, Cherwinski H, Spies T, Phillips JH, Lanier LL.

J Exp Med. 2000 Oct 2;192(7):1059-68. PMID: 11015446

Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome.

Tangye SG, Phillips JH, Lanier LL, Nichols KE.

J Immunol. 2000 Sep 15;165(6):2932-6. PMID: 10975798

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL.

Immunity. 2000 Jun;12(6):721-7. PMID: 10894171

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

Paloneva J, Kestilä M, Wu J, Salminen A, Böhling T, Ruotsalainen V, Hakola P, Bakker AB, Phillips JH, Pekkarinen P, Lanier LL, Timonen T, Peltonen L.

Nat Genet. 2000 Jul;25(3):357-61. PMID: 10888890

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.

Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9792-6. PMID: 10449773

An activating immunoreceptor complex formed by NKG2D and DAP10.

Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH.

Science. 1999 Jul 30;285(5428):730-2. PMID: 10426994

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.

Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T.

Science. 1999 Jul 30;285(5428):727-9. PMID: 10426993

Association of DAP12 with activating CD94/NKG2C NK cell receptors.

Lanier LL, Corliss B, Wu J, Phillips JH.

Immunity. 1998 Jun;8(6):693-701. PMID: 9655483

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.

Smith KM, Wu J, Bakker AB, Phillips JH, Lanier LL.

J Immunol. 1998 Jul 1;161(1):7-10. PMID: 9647200

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.

Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH.

Nature. 1998 Feb 12;391(6668):703-7. PMID: 9490415

Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes.

Phillips JH, Gumperz JE, Parham P, Lanier LL.

Science. 1995 Apr 21;268(5209):403-5.

Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid.

Lanier LL, Cwirla S, Yu G, Testi R, Phillips JH.

Science. 1989 Dec 22;246(4937):1611-3. PMID: 2531919

Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

Lanier LL, Yu G, Phillips JH.

Nature. 1989 Dec 14;342(6251):803-5.

Identification and sequence of a fourth human T cell antigen receptor chain.

Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A.

Nature. 1987 Dec 10-16;330(6148):569-72.

Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus.

Lanier LL, Weiss A.

Nature. 1986 Nov 20-26;324(6094):268-70.

Identification of antigen receptor-associated structures on murine T cells.

Allison JP, Lanier LL.

Nature. 1985 Mar 7-13;314(6006):107-9.

Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.

Lanier LL, Le AM, Phillips JH, Warner NL, Babcock GF.

J Immunol. 1983 Oct;131(4):1789-96

Expression of Lyt-1 antigen on certain murine B cell lymphomas.

Lanier LL, Warner NL, Ledbetter JA, Herzenberg LA.

J Exp Med. 1981 Apr 1;153(4):998-1003.

Novel type of murine B-cell lymphoma.

Lanier LL, Lynes M, Haughton G, Wettstein PJ.

Nature. 1978 Feb 9;271(5645):554-5.

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Lanier Lab Publications